www.BioMedPub.net

A friend of a friend made this site http://www.benchfly.com. Checked it out, it is pretty cool site with a lot of you-tube like videos for biological research purposes, some are tricks to save a lot of time, some walk you through how to fix an equipment, and some are really funny, and it is free :D....

Came across the http://www.addgene.org through a friend, it is a very resourceful site for finding the published recombinant DNA plasmids to make your final push for your publication with detailed map and sequencing information. Better than dealing with the lab who claims the vector was made 10 year...

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010 Jul 29;466(7306):627-31 Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Taka...

This is certainly not a good news for companies who are developing Sirt1 activators. Maybe it is always a good idea to use alternative methods to confirm the positive drugs, like using radioactive-labelled substrate, it should be the more reliable way to assess the enzyme activity without interferen...

Leptin has such potent effects on body weight, it holds as one of the most promising anti-obesity or anti-diabetes drug/target over more than a decade, yet nothing seems to come out positive in terms of therapeutic use in clinical applications. The potency of leptin in human is certainly diminished ...

Antidiabetic effects of IGFBP2, a leptin-regulated gene. Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Cell Metab. 2010 Jan;11(1):11-22. Rockefeller University, New York, NY 10065, USA. We tested whether leptin can ameliorate diabetes independent of weight loss by...

There are both biological/physiological and social effects of obesity in every population, would you make it clear what topic you will be writing about? Or just in general discussing the adverse effects of obesity? What are some effects of obesity on global populations? OK, im writing a paper over o...

So much have been done on JNK in adipose tissue, this is very nice data on the muscle which is the major glucose disposal organ. Yet I wonder besides regulating insulin sensitivity, what other effects of JNK in the muscle are yet to be discovered such as directly regulates glucose and lipid metaboli...

These are very interesting studies involving many hot genes that have shown to be novel therapeutic targets for metabolic disorders. The first paper showed a novel molecular pathway that may mediates nutrient sensing and downstream transcriptional regulation. The reversible acetylation and deacetyla...

Ceramide action on diabetes and obesity is a very intriguing and relatively new pathway, the sphingolipid signaling through a PKC independent fashion, the argument is what is more vital pathway that regulates metabolism and insulin resistance, there is evidence that ceramide is more important with o...

Indeed, this is very interesting gene related to important obesity inducing factors such as inflammation. I wonder if there is any difference in MCPIP expression and its targets in different fat depots with endogenously different degree of inflammation or MCP-1 production. Another thought is what if...

With so many reports on discovery of new genes that govern obesity and insulin sensitivity, PPARγ agonist is still one of the top choices searching for insulin sensitizer by big pharmas. This paper showed some promising aspects of this new drug with weak transactivity on PPARγ, if it turns out to be...

The similar topic has been discussed in this forum that antioxidant effects on metabolism. This study showed specific mitochondrial reative oxygen species clearing enzyme SOD2 expression alone can help with Alzheimer's Disease. It is difficult to adminstrate directly into CNS, but systematically adm...

A 50% reduction in Glut2 will not cause a strong diabetic phenotype in mice. The manuscript also reports that Kir6 expression is elevated and that several other genes may be affected. There are two major "biological" messages in this manuscript. First that HMGN3 is highly expressed in end...

I totally agree with DX7 that reative oxygen species are not always bad. As matter of fact they are more likely to be a necessary "evil". It is known that ROS can serve as a defense method to eliminate invading microbes, and many recent studies shows that ROS can actually mimic hormone act...

This is exciting, that we can draw some blood and tell our physiological age :) Somehow I am always confused by the biomarker study, I guess maybe It is because of years of pathway and functional study training :roll: I understand biomarkers do not necessarily have any functional linkage with the pr...

Considering the effect of mTOR in both cancer and metabolism, is there any metabolic effects regarding GOLPH factors on ER stress and metabolism? Or does it regulate cancer metabolism on glucose and/or lipid breakdown?

Interesting enough, since it seems that this CRED interacting protein CRTC2 has profound metablic effects, at least in the liver. One can not help thinking about its interacting proteins, CREB can not be the only one, right?